Regulation of hippocampal neurogenesis in adulthood
The zebrafish displays a strong neurogenerative capacity capable of regenerating a variety of tissues and complete neuronal diversity (with the exception of astrocytes, as they have yet to be identified within the zebrafish brain) with continued neurogenesis through the life span.
In recent decades the model has solidified its role in adult regeneration and neurogenesis following damage.
Some antigens can be used to measure specific stem cell stages.
For example, stem cells requires the sox2 gene to maintain pluripotency and is used to detect enduring concentrations of stem cells in CNS tissue.
are commonly used DNA labels, and are used for radiolabelling and immunohistochemistry respectively.
DNA labeling can be used in conjunction with neuronal lineage markers to determine the fate of new functional brain cells.
While the organism makes for a strong human analog, the model has its limitations not found in the previous models: higher cost of maintenance, lower breeding numbers, and the limited neurogenerative abilities.
The creation of new functional brain cells can be measured in several ways, summarized in the following sections.
Rodents display a wide range of neural circuits responsible for complex behaviors making them ideal for studies of dendritic pruning and axonal sheering.
The zebrafish, like the axolotl, has played a key role as a bridge organism between invertebrates and mammals.
The zebrafish is a rapidly developing organism that is relatively inexpensive to maintain, while providing the field ease of genetic manipulation and a complex nervous system.
In humans, new neurons are continually born throughout adulthood in two regions of the brain: However, the functional significance of nascent neurons remains controversial.
Adult neurogenesis poses many implications in terms of its functioning in learning and memory, emotion, stress, depression, and other conditions.